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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Silymarin
drug:
Interleukin-10
Research Papers that Mention the Interaction
“The results showed that Silymarin promoted Treg proliferation at 100 μM concentration after 72 h. Additionally, IL-10 , TGF-β levels, and FOXP3, JAK3, and STAT5 gene expression enhanced by Silymarin dose and time dependently.”
Silymarin Restores Regulatory T Cells (Tregs) Function in Multiple Sclerosis (MS) Patients In Vitro“We hypothesized that silymarin would suppress T‐cell proliferation and pro‐inflammatory cytokine production of virus‐ and non‐virus‐specific T cells while increasing anti‐inflammatory IL‐10 production in vivo.”
“Oral administration … liquisolid and SM revealed a significant protective efficacy against the modification of … plasma markers, brain natriuretic peptide (BNP), interleukin-10 ( IL-10 ), vascular endothelial growth factor (VEGF), and transforming growth factor (TGF)-β1 besides cardiac … dismutase (SOD), malondialdehyde (MDA), and total protein kinase-1 (Akt-1) levels.”
“Results of this part showed that silymarin significantly decreased IFNγ, RORγt and IL-17 gene expressions and upregulated Foxp3, TGF-β and IL-10 mRNA.”
Differential regulation of CD4+ T cell subsets by Silymarin in vitro and in ovalbumin immunized mice“The production of proinflammatory cytokines was investigated using ELISA kits, and the results demonstrated that silymarin dose-dependently inhibited the production of tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-10 and IL-1β in the liver.”
“In the meantime, Silymarin decreased the level of IL-10 while elevated the level of IL-2 and IFN-γ in the serum of tumor-bearing mice.”
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