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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Silymarin
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“Atomic Absorption Spectroscopy analysis and fluorescent microscopic pictures proved that silymarin reduces the increased intracellular calcium and apoptosis induction during B(a)P treatment.”
“The findings reveal that silymarin possesses substantial protective effect against B(a)P induced DNA damage and calcium mediated apoptosis by inhibiting the catalytic activity of CYP1B1 and maintaining the intracellular calcium dysregulation; hence, it could be considered as a potential protective agent for environmental contaminant induced immunotoxicity.”
Silymarin attenuates benzo(a)pyrene induced toxicity by mitigating ROS production, DNA damage and calcium mediated apoptosis in peripheral blood mononuclear cells (PBMC).“ Silymarin also inhibited TNF-α-induced intracellular calcium.”
“It was found that silymarin stimulated alkaline phosphatase (ALP) activity and calcium nodule formation in a dose-dependent manner with a substantial effect on osteoblast proliferation.”
“It is also shown that silymarin induces mitochondrial swelling, a drop in the transmembrane potential, as well as Ca2+ release.”
“Data obtained rule out the possibility that the antiperoxidative action of Silymarin was due to an interaction of this drug with Fe 2+ .”
Inhibitory action of silymarin of lipid peroxide formation in rat liver mitochondria and microsomes.“Subsequently, we found that silymarin induced disturbances in calcium homeostasis via the cytosolic and mitochondrial accumulation of calcium.”
Potential role of potassium and chloride channels in regulation of silymarin‐induced apoptosis in Candida albicans
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