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Last Updated: 3 years ago

Possible Interaction: Silymarin and Aldesleukin

supplement:

Silymarin

drug:

Aldesleukin

Research Papers that Mention the Interaction

“ELISA analyses indicated that silymarin significantly inhibited IL-2 and IFN-gamma production.”
Silymarin suppress CD4+ T cell activation and proliferation: effects on NF-kappaB activity and IL-2 production.
Pharmacological research  •  2010  |  View Paper
“The expression of IL-2 and IL-4 were reduced in mice treated with 10 and 50 mg/kg of silymarin although only the 10 mg/kg group was significantly different from control.”
Physiological responses of a natural antioxidant flavonoid mixture, silymarin, in BALB/c mice: III. Silymarin inhibits T-lymphocyte function at low doses but stimulates inflammatory processes at high doses.
Planta medica  •  2003  |  View Paper
“In contrast, the expressions of IL-2 and IL-4 were decreased by silymarin , while MHC II expression did not change.”
Physiological responses to a natural antioxidant flavonoid mixture, silymarin, in BALB/c mice: II. alterations in thymic differentiation correlate with changes in c-myc gene expression.
Planta medica  •  2002  |  View Paper