Possible Interaction: Silicon and Calcium Supplement

“Serum alkaline phosphatase and osteocalcin, two bone formation biomarkers tested, were not significantly altered, but urinary calcium and phosphorous excretion tended to decrease with silicon supplementation.”

“It has been suggested that in the early evolutionary stages of planetary life silicon may well have competed with calcium for dominance in the role of main structural element.”

“It was also observed that extensive CA adsorption on the outer surface of the silicon particles negates the advantages offered by nanoscale confinement.”

“Besides, the treatment with genistein and silicon for 10 weeks increased the serum levels of calcium and phosphorus in the OVX rats; serum calcium and serum phosphorus in the OVX-GEN-Si group were higher than those in the OVX-GEN and OVX-Si group (P < 0.05).”

“Previous studies have suggested that silicon (Si) had positive effects on bone, but such benefits from Si may be dependent on calcium status.”

“This study tests the hypothesis that silicon and calcium ions combinatorially target gene expression during osteoblast differentiation.”

“The antagonistic relations of high Si levels with calcium and magnesium were deemed to be the mechanisms through which high Si imposes its deleterious effects on bone size and strength.”

“In the adult normal the ingestion of silicon modifies the concentration of Ca and Mg of plasma and tissues most often opposite ways according to the mineral (silicate Na) or organic form (SMTO) of the administration.”

“It is suggested that silicon is associated with calcium in an early stage of calcification.”

“The addition of Si affected the absorption of other metal elements in rice seedlings, including calcium (Ca), magnesium (Mg) and manganese (Mn).”

“The concentrations of Ca and Mg in root and aboveground parts were significantly increased by Si addition under bilateral Cd-stress (Cd-Cd+Si), but Mn concentration was changed with the stress degree of Cd.”