supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Sevoflurane
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“In addition, the in vivo study further confirmed that sevoflurane inhibited tumor growth via Ca2+ -dependent CaMKII/JNK cascade.”
Sevoflurane modulates the cancer stem cell-like properties and mitochondrial membrane potential of glioma via Ca2+-dependent CaMKII/JNK cascade.“ Sevoflurane and desflurane were less potent than isoflurane in altering intracellular calcium , and produced less apoptosis.”
“ Sevoflurane affects breast cancer cell survival via modulation of intracellular Ca 2 + homeostasis.”
“BACKGROUND: Halothane, isoflurane, and sevoflurane exert negative inotropic side effects, generally mediated via a reduced availability of intracellular calcium.”
“Although the mechanism remains unclear, evidence points to the increase of intracellular calcium after administration of Sevoflurane.”
Sevoflurane increases intracellular calcium to induce mitochondrial injury and neuroapoptosis.“The Ca2+ paradox was significantly suppressed by sevoflurane administered for 3 min before and during Ca2+ repletion (Post) or during Ca2+ depletion and repletion (Postlong), and Postlong was more beneficial than Post application.”
“In contrast, sevoflurane initially inhibited frequency of Ca2+ release (to 10% of control), whereas its removal induced a burst of spontaneous Ca2+ release.”
“Halothane did not affect Ca2+ extrusion from the cell, but both isoflurane and sevoflurane inhibited it.”
“Halothane, enflurane, and isoflurane all enhance, while sevoflurane attenuates, the Ca2+ -induced Ca2+-release mechanism.”
“Furthermore, sevoflurane caused more pronounced accumulation of intracellular calcium than did halothane and isoflurane.”
Halothane suppresses the increase in intracellular calcium concentration of isolated rat myocytes during hydrogen peroxide perfusion
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback