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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Serum Albumin, Human
drug:
Saracatinib
Research Papers that Mention the Interaction
“Addition of SCB to HSA significantly defended the thermal denaturation of the protein, though it perturbed the surrounding medium around Tyr and Trp residues.”
“Analysis of the fluorescence quenching data along with absorption results confirmed the complex formation between SCB and HSA , based on the inverse correlation of the Stern-Volmer constant (KSV ) with temperature and hyperchromic effect in the absorption spectra.”
“Analysis of the fluorescence quenching data along with absorption results confirmed the complex formation between SCB and HSA , based on the inverse correlation of the Stern-Volmer constant (KSV) with temperature and hyperchromic effect in the absorption spectra.”
“… SCB … HSA was evident from the binding constant, Ka value (1.08-0.74 × 104 M-1), while the SCB - HSA complexation was anticipated to be … hydrogen bonds, as revealed from the thermodynamic data (ΔS = + 29.40 J mol-1 K-1 and ΔH = - 13.90 kJ mol-1).”
“… SCB … HSA was evident from the binding constant, Ka value (1.08–0.74 × 104 M−1), while the SCB−HSA complexation was anticipated to be … hydrogen bonds, as revealed from the thermodynamic data (ΔS = + 29.40 J mol−1 K−1 and ΔH = − 13.90 kJ mol−1).”
Biophysical and computational view on the in vitro combination between an anticancer drug, saracatinib and human serum albumin
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