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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Serum Albumin, Human
drug:
Ruxolitinib
Research Papers that Mention the Interaction
“Docking simulations indicate that ruxolitinib binds to multiple sites of HSA.”
“Given the high plasma concentration of HSA, ruxolitinib trapping may be relevant in vivo.”
“Moreover, HSA selectively blocks, in a dose dependent manner, the cytotoxic activity of ruxolitinib in JAK2V617F+ cellular models for MPN, in vitro.”
“ Ruxolitinib binds to the FA1 and FA7 sites of HSA with high affinity (K r = 3.1 μM and 4.6 μM, respectively, at pH 7.3 and 37.0 °C).”
Ruxolitinib binding to human serum albumin: bioinformatics, biochemical and functional characterization in JAK2V617F+ cell models
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