Possible Interaction: Serum Albumin, Human and Doxorubicin Hydrochloride

“ DOX complexation induced major alterations of HSA and BSA conformations, while did not alter β-LG secondary structure.”

“Molecular modeling studies showed stronger binding of DOX with HSA than BSA and β-LG with the free binding energies of -10.75 (DOX-HSA), -9.31 (DOX-BSA) and -8.12kcal/mol (DOX-β-LG).”

“Several attempts have been made to enhance doxorubicin DOXO ) concentrations in tumour cells by drug conjugation with human albumin (HSA).”

“Type I agents include cis-diamminedichloroplatinum (II), 4'-(9-acridinylamino)methanesulphon-m-anisidide, neocarzinostatin, nitrogen mustard, adriamycin , daunorubicin and mitomycin C--drugs whose biological activities are reduced in the presence of HA.”

“Our results demonstrate that adriamycin react with HSA and the binding to the protein molecule has a very distinct influence on the stability of ADR in aqueous solutions.”

“The quantitative precipitating test supports distinct changes in the conformation upon ADR binding that decreases the ability of HSA to precipitate with its antibody.”

“ Lactosaminated human albumin coupled doxorubicin also hindered the development of new neoplastic nodules, which was unaffected by the free drug.”

“Furthermore, detailed procedures to precisely monitor and control both DOX payload and binding strength to HSA are established.”