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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Serum Albumin, Human
drug:
Cpt-11
Research Papers that Mention the Interaction
“The melting point (Tm) of HSA was decreased in the presence of CPT-11 as compared to native HSA that was determined by DSC for both isoforms of HSA.”
“Therefore, CPT-11 plays an important role in HSA stability and protein–ligand interactions.”
Biophysical and molecular docking insight into interaction mechanism and thermal stability of human serum albumin isoforms with a semi-synthetic water-soluble camptothecin analog irinotecan hydrochloride“The binding constants of lactone ring-opened forms (A form) of CPT and CPT-11 with HSA were larger than those of the intact lactone forms (L form).”
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