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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Serum Albumin, Human
drug:
Cositecan
Research Papers that Mention the Interaction
“MethodsAn AGP-immobilized protein column was used to develop HPLC methods to evaluate the effect(s) of physiologically relevant HSA and … concentrations on the lactone/carboxylate ratio and hydrolysis kinetics of Karenitecin, camptothecin (CPT), and topotecan (TPT).ResultsPhysiologically relevant concentrations of HSA and AGP substantially slowed Karenitecin lactone hydrolysis.”
Stabilization of the Karenitecin® lactone by alpha-1 acid glycoprotein
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