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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Serum Albumin, Human
drug:
Axitinib
Research Papers that Mention the Interaction
“ AXT binding to the protein produced significant alterations in both secondary and tertiary structures of HSA , as revealed from the far-UV and the near-UV CD spectral results.”
“Fluorescence quenching titration results demonstrated moderately strong binding affinity between AXT and HSA based on the binding constant value (1.08±0.06×10(5)M(-1)), obtained in 10mM sodium phosphate buffer, pH7.4 at 25°C.”
“This was also confirmed from alteration in the UV-vis spectrum of HSA upon AXT addition.”
“Three-dimensional fluorescence spectral results indicated significant microenvironmental changes around Trp and Tyr residues of HSA upon complexation with AXT.”
Binding of an anticancer drug, axitinib to human serum albumin: Fluorescence quenching and molecular docking study.
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