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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
Research Papers that Mention the Interaction
“ Abstract Yohimbine , 5 or 20 mg/kg given intraperitoneally, increased the concentration of brain serotonin and decreased that of 5-HIAA, in the rat.”
The effect of yohimbine on brain serotonin metabolism, motor behavior and body temperature of the rat.“ Yohimbine antagonized both dihydroergotamine and 5-HT at about 60 times higher concentrations than required against noradrenaline whereas pizotifen inhibited responses to both dihydroergotamine and 5-HT at about 100 times lower concentrations than those to noradrenaline.”
“The effect of 5-HT to inhibit forskolin-stimulated activity was partially antagonised by spiperone, yohimbine and pindolol, with each of these compounds showing some partial agonist activity.”
“The summation of serotonin stimulation of PI turnover by a combination of both epinephrine and serotonin was blocked by either yohimbine or ketanserin.”
“Also, co-administration of serotonin and yohimbine significantly amplified the hypophagic effect of serotonin.”
Serotonin-induced hypophagia is mediated via α2 and β2 adrenergic receptors in neonatal layer-type chickens“Electrophysiology data indicate that 5-HT neurons in the cocaine group exposed to yohimbine had increased amplitude of inhibitory postsynaptic currents compared to yoked-saline controls exposed to yohimbine or unstressed animals in both drug groups.”
“The contraction was blocked by the 5-HT(1,2) receptor antagonist methysergide and was markedly reduced by the 5-HT(2B) receptor antagonist, yohimbine , which also profoundly affected 5-HT induced contractions in fundic strips.”
“Since yohimbine previously has been demonstrated to interfere both with noradrenaline (NA) and serotonin ( 5-HT) neurochemistry, and, in addition, shows affinity for the BDZ binding site, we have focused on the putative involvement of these neuronal systems in the yohimbine-induced anticonflict effect.”
“Taken together, the results in the present behavioral paper indicate that the anticonflict effect of yohimbine involves both increased NA and decreased 5-HT activity, and that direct or indirect activation of BDZ receptors may also be involved.”
“The anticonflict effect of yohimbine was dose-dependently antagonized also by the 5-HT precursor L-5-hydroxytryptophan (25–100 mg/ kg, i.p.).”
“ Yohimbine was a potent antagonist of 5-hydroxytryptamine.”
“The differences between the two drugs may result from the interaction of yohimbine with receptors for 5-hydroxytryptamine.”
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