Possible Interaction: Serotonin and Vitamin C

“In colon epithelial …), direct application of 5-HT induced production of reactive oxygen species (ROS) and monocyte-epithelial adhesion, an … not only by 5-HT receptor antagonists (tropisetron, RS39604, and SB269970), antioxidants ( ascorbic acid , apocynin), and various inhibitors of NADPH oxidase (DPI), …), but also by transfection with Nox2 siRNA.”

“Migration blockage is mediated by reactive oxygen species (ROS) generation since antioxidants, such as Vit C and Cu-Zn superoxide dismutase, prevent the inhibitory effects of 5-HT on cell migration.”

“For all the patients studied, the effect of vitamin C on the response to serotonin was significantly correlated with the intimal thickening.”

“ Vitamin C spiked during the sample pretreatment and storage periods significantly retarded the oxidation of dopamine and serotonin and improved the neurotransmitter stability.”

“Furthermore, pretreatment with ascorbic acid (400 mg/kg) or deprenyl (2 mg/kg) prevented the l-dopa–induced decreases in 5-HT neurons.”

“In addition, 5-HT content was decreased significantly in the DRN and prefrontal cortex by l-dopa treatment, effects that were prevented by ascorbic acid pretreatment.”

“However, Vitamin C (VC) enhanced the contractile response of both groups to higher dosages of 5-HT.”

“Binding was enhanced in the presence of ascorbic acid but was completely inhibited by (-)-isoprenaline (100 microM), serotonin ( 5-HT) (10 microM) and phentolamine (10 microM).”

“Apomorphine proved to be the most effective compound, fully antagonizing the effect of ascorbic acid at a concentration of 10 −6 M. A partial inhibition of the effect of ascorbic acid was induced by 10 −4 M serotonin , desipramine, imipramine and LSD.”

“Similar degrees of bronchoconstriction were produced by 5-hydroxytryptamine (5 pg), bradykinin (10 pg), and histamine (5 pg), and all these actions were prevented by previously injecting ascorbic acid (500 mg/kg) in neutral solution within 10 min of the injection of the spasmogens (see Fig. 1). ,”

“A single administration of vitamin C to mice induced time- and dose-dependent increases in plasma concentrations of the serotonin metabolite 5-hydroxyindole acetic acid (5-HIAA), a marker for vascular disrupting effects.”

“High-dose vitamin C administration decreased tumor serotonin concentrations, consistent with the release of serotonin from platelets and its metabolism to 5-HIAA.”