Possible Interaction: Serotonin and Tyrosine

“Thus, for example, brain levels of tryptophan, tyrosine , or choline can control the rates at which neurons synthesize serotonin , dopamine, or acetylcholine, respectively.”

“The changes observed, particularly in DA and 5-HT metabolites, provide further evidence for an inhibitory role of brain 5-HT systems in the mediation of the behavioral effects of d-amphetamine and the catecholamine precursors, L-tyrosine and L-DOPA.”

“Other substances found to inhibit the iodination of tyrosine by the thyroid particulate fraction are DPNH, TPNH, cysteine, epinephrine, norepinephrine, serotonin , ergothioneine, thiohistidine and dichlorophenol.”

“In addition, we observed a significant increase in tyrosine phosphorylation and changes in sperm motility after 5-HT treatment.”

“viii) 5-HT stimulated tyrosine phosphorylation of c-Src kinase and PKCδ.”

“These observations suggest that a high level of tyrosine in serum can affect the metabolism in the brain of dopamine and serotonin.”

“Moreover, 5-HT stimulates glucose uptake and up-regulates PFK activity through the 5-HT2A receptor, resulting in the phosphorylation of a tyrosine residue of PFK and the intracellular redistribution of PFK within skeletal muscle.”

“ Tyrosine increased dopamine and norepinephrine turnover rates and decreased in serotonin turnover rate in the brain.”

“These effects occur due to tyrosine phosphorylation of the enzyme that is 2-fold enhanced upon 5-HT stimulation of skeletal muscles preparation.”

“In fact, 5-HT was found to stimulate tyrosine phosphorylation of a number of proteins, and this phosphorylation was inhibited by W7.”