Possible Interaction: Serotonin and Tubocurarine

“This action was similar to that of granisetron and ICS 205-930, but differed from that of GR38032F and (+)-tubocurarine which produced clear rightward shifts of the concentration-response curve to 5-HT.”

“Low concentrations of (+)-tubocurarine [+)-Tc) also blocked the response to 5-HT (IC50 = 0.8 nM), but other nicotinic cholinoceptor antagonists (gallamine, vecuronium and trimetaphan) were ineffective when applied at a relatively high concentration (1 microM).”

“It appears to be mediated by a distinct receptor/ionophore as excitation by ACh and 5-HT are both antagonized by d-tubocurarine.”

“ d-Tubocurarine reversibly antagonized the excitatory action of 5-HT on cells F 4, 5 and 6 and converted tryptamine and 6-HT excitation to inhibition.”

“ d-Tubocurarine or picrotoxin at relatively low concentrations blocked ACh, 5-HT and GABA depolarizations without affecting membrane properties.”

“Benzoquinonium chloride, d-tubocurarine and morphine, the latter to a slight extent, antagonize the tone increase while augmenting the beat induced by 5-hydroxytryptamine.”

“ d-Tubocurarine in concentrations that had no effect upon histamine depressed the effects produced by serotonin or nicotine.”