Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 months ago

Possible Interaction: Serotonin and Threonine

supplement:

Threonine

Research Papers that Mention the Interaction

Mimicking the effect of ASCT2 down-regulation, treatment of HEK-293 cells and neurons with the ASCT2 inhibitor D-threonine also increases 5-HT uptake.
The Biochemical journal  •  2016  |  View Paper
5-HT resulted in (1) an uncoupling of receptor from G proteins as evidenced by a loss of high-affinity agonist binding sites and a …) a decreased ability of the receptor to inhibit cAMP accumulation, and (3) increased phosphorylation of the 5-HT1A receptor on serine and threonine residues.
Biochemistry  •  1995  |  View Paper
Both phorbol esters and serotonin increase the percentage of kinase phosphorylated at threonine 613 inAplysia neurons.
The Journal of Biological Chemistry  •  1999  |  View Paper