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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Serotonin
supplement:
Resveratrol
Research Papers that Mention the Interaction
“ Resveratrol induced more potent vasodilatation of serotonin‐ and 100 mM K+‐precontracted HUV than naringenin.”
The Different Effects of Resveratrol and Naringenin on Isolated Human Umbilical Vein: The Role of ATP‐Sensitive K+ Channels“Furthermore, resveratrol and fluoxetine increased serotonin (5-HT) levels and downregulated the mRNA expression of 5-HT transporter (SERT) in the hippocampus.”
Effects of resveratrol on the levels of ATP, 5-HT and GAP-43 in the hippocampus of mice exposed to chronic unpredictable mild stress“Bath … 5-HT reduced the peak amplitude of excitatory postsynaptic … in MMNs by electrical stimulation of the MesV afferents (eEPSPs), and this inhibitory effect of 5-HT on eEPSPs was replicated with the 5-… receptor agonist CP-93129 but not by the 5-HT1A receptor agonist 8-OH-DPAT.”
“The EC(50) of resveratrol was 28.0±2.4 µM. The presence of resveratrol caused a leftward shift of 5-HT concentration-response curve.”
“In addition, resveratrol significantly decreased the contractile responses of 5-HT , KCl and CaCl(2), and shifted their cumulative concentration-response curves to the right.”
“ Resveratrol can significantly increase the levels of neurotransmitters DA and 5-HT in the prefrontal cortex and increase the expression of NPY in the brain, which can play an antagonistic role in depression.”
Therapeutic effect of resveratrol on mice with depression
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