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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Serotonin
supplement:
Proanthocyanidin
Research Papers that Mention the Interaction
“Further studies showed that … of 20 µg/ml proanthocyanidin caused not only a rightward shift of the dose-response curve for 5-HT (EC(50) shift from 2.7±0.4 to 6.2±0.5 µM), but also a decreased E(max) (inhibition by 37.5±1.3%).”
“High concentrations (≧30 µg/ml) of proanthocyanidin caused a concentration-dependent inhibition of the activation and desensitization of currents induced by 30 µM 5-HT.”
“ Proanthocyanidin also produced a concentration-dependent inhibition of currents induced by 30 µM 5-HT , near-maximal concentration (IC(50)=22.1±0.4 µg/ml, Hill coefficient=2.4±0.1).”
“… proanthocyanidin (… 5-HT (near EC(50)) produced a slight inhibition of 5-HT-induced inward peak current (I(5-HT)) in NCB-20 cells, but pretreatment …-HT) in an irreversible, concentration- and time-dependent manner (IC(50)=6.5±0.4 µg/ml, Hill coefficient=2.5±0.1).”
Effects of grape seed proanthocyanidin on 5-hydroxytryptamine(3) receptors in NCB-20 neuroblastoma cells.“In addition, the neurochemical and neuropharmacological assays showed that proanthocyanidin produced a marked increase of 5-HT levels at 25 and 50mg/kg in three brain regions, the frontal cortex, hippocampus and hypothalamus.”
Antidepressant-like effect of low molecular proanthocyanidin in mice: Involvement of monoaminergic system
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