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Possible Interaction: Serotonin and Phosphatidylinositol 4,5-Diphosphate

Research Papers that Mention the Interaction

The addition of serotonin to preparations of 32P-labelled human platelets resulted in a time- and dose-dependent hydrolysis of [32P]phosphatidylinositol 4,5-bisphosphate (PIP2) and formation of [32P]phosphatidic acid (PA).
Drug and alcohol dependence  •  1989  |  View Paper
The 32P content of phosphatidylinositol 4-phosphate (PIP) and phosphatidylinositol 4,5-bisphosphate (PIP2) only slightly increased during the first minute after addition of serotonin and became more apparent on prolonged stimulation.
Biochimica et biophysica acta  •  1987  |  View Paper
In blowfly salivary glands, 5-hydroxytryptamine stimulated a rapid and sustained loss of [3H]inositol, [32P]phosphatidylinositol, phosphatidylinositol 4-phosphate, and phosphatidylinositol 4,5-bisphosphate.
In the absence of Ca2+, 5-hydroxytryptamine stimulated a rapid but transient loss of labeled phosphatidylinositol 4,5-bisphosphate.
The American journal of physiology  •  1984  |  View Paper
Stimulation of insect salivary glands with 5-hydroxytryptamine for 6 min provoked a rapid disappearance of [3H]phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] and [3H]phosphatidylinositol 4-phosphate (PtdIns4P) but had no effect on the level of [3H]phosphatidylinositol (PtdIns).
The fact that these increases in Ins(1,4,5)P3 and Ins(1,4)P2 precede in … the level of inositol 1-phosphate or inositol provides a clear indication that the primary action of 5-hydroxytryptamine is … of PtdIns(4,5)P2 to yield diacylglycerol …,4,5)P3.
The Biochemical journal  •  1983  |  View Paper
Both dopamine and serotonin , however, dose-dependently inhibited the formation of radiolabelled TPI and PA.
Peptides  •  1982  |  View Paper