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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Serotonin
supplement:
Peppermint Oil
Research Papers that Mention the Interaction
“Both peppermint oil and (‐)‐menthol inhibited [14C]guanidinium influx through 5‐HT3 receptor channels as well as contractions of the ileum induced by serotonin.”
Mode of action of peppermint oil and (‐)‐menthol with respect to 5‐HT3 receptor subtypes: binding studies, cation uptake by receptor channels and contraction of isolated rat ileum“ Peppermint oil has antiemetic and antispasmodic effects on the gastric lining and colon, which may be related to inhibition of muscular contractions induced by serotonin and substance P4.”
“ Peppermint oil markedly attenuated contractile responses in the guinea pig taenia coli to acetylcholine, histamine, 5-hydroxytryptamine , and substance P. Peppermint oil reduced contractions evoked by potassium depolarization and calcium contractions evoked in depolarizing Krebs solutions in taenia coli.”
The mechanism of action of peppermint oil on gastrointestinal smooth muscle. An analysis using patch clamp electrophysiology and isolated tissue pharmacology in rabbit and guinea pig.“Further it was shown that peppermint oil inhibits non-competively 5-hydroxytryptamin (Serotonine) and substance P induced smooth muscle contraction in animal-models.”
Essential plant oils and headache mechanisms.
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