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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Serotonin and Glutamate

supplement:

Glutamate

Research Papers that Mention the Interaction

Dextromethorphan may be releasing 5-HT by blocking the NMDA receptors and thereby counteracting the inhibitory influence of l-glutamate on 5-HT release.
Indian journal of experimental biology  •  2005  |  View Paper
L-glutamate (10(-4) M) stimulated 5-HT metabolism in both types of cells, effect totally blocked by PK26124 (10(-6) M).
Neurochemistry International  •  1993  |  View Paper
This may result from a reduction of the postsynaptic sensitivity of motoneurons to excitatory amino acid transmitters because 5-HT significantly depressed motoneuron depolarizations produced by addition of L-glutamate and L-aspartate to the superfusate.
Brain Research  •  1992  |  View Paper