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Last Updated: 2 years ago

Possible Interaction: Serotonin and Genistein

supplement:

Genistein

Research Papers that Mention the Interaction

Moreover, genistein induced the relaxation of HUA rings precontracted either with serotonin or a depolarizing high-extracellular K+ solution, hinting at a reduction of extracellular Ca2+ entry to the cell.
Journal of Physiology and Biochemistry  •  2009  |  View Paper
Uptake of tritiated serotonin into human platelets was found to be rapidly inhibited by the tyrosine kinase inhibitors, genistein and methyl 2,5-dihydroxycinnamate.
European journal of pharmacology  •  1995  |  View Paper
GEN treatment also inhibited SPS-induced decreases in serotonin (5-HT) levels in the medial prefrontal cortex and hippocampus.
These increased 5-HT concentrations in response to GEN treatment could be partially attributed to the ratio of 5-hydroxyindoleacetic acid/5-HT in the hippocampus.
Journal of medicinal food  •  2020  |  View Paper
Furthermore, in these rats, genistein enhanced serotonergic transmission in the amygdala, including upregulation of tryptophan hydroxylase, serotonin , and phosphorylated (p)-CaMKII and p-CREB, as well.
Psychiatry Research  •  2017  |  View Paper
Genistein strongly inhibited the [Ca2+]i increase evoked by 5-HT (74.0±7.3%, n=11, p<0.05), and had a smaller effect on high K+ induced [Ca2+]i increase (19.9±4.0%, n=7, p<0.05).
In conclusion, in rat aortic smooth muscle, genistein is capable of diminishing the increase in [Ca2+]i and in force evoked by 5-HT and high K+ solution, and of decreasing the frequency of [Ca2+]i oscillations induced by 5-HT.
Interestingly, during prolonged application of 5-HT , the [Ca2+]i oscillated and a short (90 s) preincubation with genistein (20 μM) significantly diminished the frequency of the oscillations.
Journal of Physiology and Biochemistry  •  2009  |  View Paper
Genistein reduces platelet accumulation of serotonin , whose constrictor properties are augmented by dyslipoproteinemia and atherosclerosis.
Coronary artery disease  •  1998  |  View Paper
Tyrphostin A23, genistein , and diadzein (30 microM) failed to reduce the contraction caused by 5-HT.
Journal of neurosurgery  •  1998  |  View Paper
RESULTS The tyrosine kinase inhibitor, ge estein, s ignificantly inhibited the magnitude of contractions induced by phorbol ester, endothelin, angiotensin, and ser otonin.
Journal of vascular surgery  •  1997  |  View Paper
Importantly, aortic contraction to 5-HT was shifted (5-fold rightward) and reduced (69% control) by genistein but not daidzein.
Journal of vascular research  •  1996  |  View Paper
Pre‐incubation with genistein or tyrphostin markedly inhibited the transient rise in [Ca2+]i evoked by serotonin or phenylephrine.
FEBS letters  •  1995  |  View Paper
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