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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Moreover, genistein induced the relaxation of HUA rings precontracted either with serotonin or a depolarizing high-extracellular K+ solution, hinting at a reduction of extracellular Ca2+ entry to the cell.”
Genistein effects on Ca2+ handling in human umbilical artery: inhibition of sarcoplasmic reticulum Ca2+ release and of voltage-operated Ca2+ channels“Uptake of tritiated serotonin into human platelets was found to be rapidly inhibited by the tyrosine kinase inhibitors, genistein and methyl 2,5-dihydroxycinnamate.”
“ GEN treatment also inhibited SPS-induced decreases in serotonin (5-HT) levels in the medial prefrontal cortex and hippocampus.”
“These increased 5-HT concentrations in response to GEN treatment could be partially attributed to the ratio of 5-hydroxyindoleacetic acid/5-HT in the hippocampus.”
Genistein Prevents Single Prolonged Stress-Induced Cognitive Impairment in a Post-Traumatic Stress Disorder Rat Model via Activation of the Serotonergic System.“Furthermore, in these rats, genistein enhanced serotonergic transmission in the amygdala, including upregulation of tryptophan hydroxylase, serotonin , and phosphorylated (p)-CaMKII and p-CREB, as well.”
“ Genistein strongly inhibited the [Ca2+]i increase evoked by 5-HT (74.0±7.3%, n=11, p<0.05), and had a smaller effect on high K+ induced [Ca2+]i increase (19.9±4.0%, n=7, p<0.05).”
“In conclusion, in rat aortic smooth muscle, genistein is capable of diminishing the increase in [Ca2+]i and in force evoked by 5-HT and high K+ solution, and of decreasing the frequency of [Ca2+]i oscillations induced by 5-HT.”
“Interestingly, during prolonged application of 5-HT , the [Ca2+]i oscillated and a short (90 s) preincubation with genistein (20 μM) significantly diminished the frequency of the oscillations.”
“ Genistein reduces platelet accumulation of serotonin , whose constrictor properties are augmented by dyslipoproteinemia and atherosclerosis.”
“Tyrphostin A23, genistein , and diadzein (30 microM) failed to reduce the contraction caused by 5-HT.”
“RESULTS The tyrosine kinase inhibitor, ge estein, s ignificantly inhibited the magnitude of contractions induced by phorbol ester, endothelin, angiotensin, and ser otonin. ”
“Importantly, aortic contraction to 5-HT was shifted (5-fold rightward) and reduced (69% control) by genistein but not daidzein.”
“Pre‐incubation with genistein or tyrphostin markedly inhibited the transient rise in [Ca2+]i evoked by serotonin or phenylephrine.”
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