Possible Interaction: Serotonin and Calcium Supplement

“Coordination between either serotonin or melatonin and calcium was not favoured.”

“ Calcium (1.3 mmol/L) had a weak inhibiting effect on serotonin uptake in blood platelets, whereas no effect was observed in synaptosomes.”

“In different types of neurone, activation of ~-adrenergic, GABAB, adenosine A~, dopamine, 5-HT,/~ , 6and x-opioid, muscarinic acetylcholine, neuropeptide Y and somatostatin receptors results in inhibition of Ca 2÷ currents (for review see Tsien et al., 1988).”

“This enabled us to show that 5-HT induced an increase in intracellular calcium.”

“The synergism of 5-HT and PAF in platelet aggregation was inhibited by calcium (Ca2+) channel blockers, verapamil and diltiazem, phospholipase C (PLC) inhibitor, U73122, cyclooxygenase (COX) inhibitor, indomethacin, and MEK inhibitor, PD98059.”

“The use of the two methods of calcium influx showed that serotonin stimulates calcium uptake into platelets.”

“In this study, serotonin 5-HT ) was found to diminish the intracellular calcium , [Ca2+]i, concentrations in a dose-dependent manner in Fura-2-loaded human leukemia (K 562) cells.”

“ Serotonin produced oscillatory, quantal contractions in the presence of calcium ; in the absence of extracellular calcium, it elicited only concentration-dependent graded contractions.”

“However, 5-hydroxytryptamine caused contractions amounting to 52% of the maximum response obtained by re-addition of Ca++ , and this response was abolished by 10(-6) M of nifedipine.”

“In the presence of either KCl or 5-hydroxytryptamine , subsequent addition of Ca++ caused reproducible contractions which were also inhibited by nifedipine.”

“Stimulation by ADP and serotonin increased Ca++ concentration, the change being greatest in patients with spastic angina pectoris.”