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Last Updated: 2 years ago

Possible Interaction: Serotonin and Adrenocorticotropic Hormone

Research Papers that Mention the Interaction

This differential response pattern relates to the distinct pathways through which serotonin may activate the corticotrophic and the lactotrophic systems.
Journal of psychiatric research  •  1997  |  View Paper
These results support the hypothesis that serotonin is involved in the regulation of PRL, cortisol, and ACTH in humans.
The Journal of clinical endocrinology and metabolism  •  1989  |  View Paper
In healthy people serotonin seems to have a stimulatory role in the regulation of ACTH secretion, and the effect of ketanserin in reducing the ACTH response to hypoglycaemia suggested that it might prove useful in Nelson's syndrome.
British medical journal  •  1984  |  View Paper
Controversy still exists regarding the role of serotonin in the regulation of ACTH secretion.
These findings support a stimulatory role for serotonin in the regulation of ACTH secretion in man.
The Journal of clinical endocrinology and metabolism  •  1984  |  View Paper
CRH was found to have a major role but not a complete responsibility in the 5-HT-… ACTH, since immunoneutralisation of CRH inhibited the POMC gene expression and the ACTH response and since 5-HT and 5-HT antagonists … to modulate the ACTH release from anterior … cells in vitro.
It can be concluded that 5-HT is involved in basal and stress-induced regulation of PRL, ACTH , AVP and oxytocin mainly via the 5-HT2A+2C receptors but other receptors are also important but differs from hormone to hormone.
Serotonin affect the secretion of CRH and ACTH both at the hypothalamic, pituitary portal and pituitary gland level, and possibly also at the adrenal level.
Danish medical bulletin  •  2007  |  View Paper
In particular, 5-HT is involved in the stimulation of ACTH secretion during stress.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme  •  1998  |  View Paper
Corticosterone, ACTH , and CRF release in vivo is increased in rats by drugs that enhance serotonin function, including serotonin precursors, serotonin uptake inhibitors, serotonin releasers , and direct-acting serotonin agonists.
Frontiers in neuroendocrinology  •  1992  |  View Paper
Increasing brain 5-hydroxytryptamine 5-HT ) function in humans raises plasma concentrations of prolactin, growth hormone and ACTH.
Journal of Neuroscience Methods  •  1990  |  View Paper
Direct-acting serotonin agonists, serotonin uptake inhibitors, serotonin releasers and the serotonin precursor L-5-hydroxytryptophan all increase adrenocorticotrophin (ACTH) and corticosterone release.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology  •  1990  |  View Paper
Serotonin has been implicated as exercising both stimulation and inhibition of ACTH release.
Annals of the New York Academy of Sciences  •  1977  |  View Paper
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