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“This differential response pattern relates to the distinct pathways through which serotonin may activate the corticotrophic and the lactotrophic systems.”
The Journal of clinical endocrinology and metabolism • 1989 | View Paper
“In healthy people serotonin seems to have a stimulatory role in the regulation of ACTH secretion, and the effect of ketanserin in reducing the ACTH response to hypoglycaemia suggested that it might prove useful in Nelson's syndrome.”
The Journal of clinical endocrinology and metabolism • 1984 | View Paper
“CRH was found to have a major role but not a complete responsibility in the 5-HT-… ACTH, since immunoneutralisation of CRH inhibited the POMC gene expression and the ACTH response and since 5-HT and 5-HT antagonists … to modulate the ACTH release from anterior … cells in vitro.”
“It can be concluded that 5-HT is involved in basal and stress-induced regulation of PRL, ACTH , AVP and oxytocin mainly via the 5-HT2A+2C receptors but other receptors are also important but differs from hormone to hormone.”
“ Serotonin affect the secretion of CRH and ACTH both at the hypothalamic, pituitary portal and pituitary gland level, and possibly also at the adrenal level.”
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme • 1998 | View Paper
“Corticosterone, ACTH , and CRF release in vivo is increased in rats by drugs that enhance serotonin function, including serotonin precursors, serotonin uptake inhibitors, serotonin releasers , and direct-acting serotonin agonists.”
Journal of Neuroscience Methods • 1990 | View Paper
“Direct-acting serotonin agonists, serotonin uptake inhibitors, serotonin releasers and the serotonin precursor L-5-hydroxytryptophan all increase adrenocorticotrophin (ACTH) and corticosterone release.”