Possible Interaction: Serine and Vitamin B 6

“Both pyridoxine and serine synergistically rescued embryonic developmental defects in zebrafish got2a morphants.”

“Whereas pyridoxine appears to be necessary for the production of "C1" units from serine which are required for the biosynthesis of nucleic acids, it seems likely that pantothenic acid is involved in the secretion of newly-synthesized proteins into the extracellular compartment.”

“We found that pyridoxine at concentrations of 10 (-3) M, or greater significantly inhibited rat mast cell degranulation and histamine release induced by phospholipase A, compound 48/80, antigen (egg albumin) or a mixture of dextran and phosphatidyl serine , respectively.”

“However, with increasing vitamin B6 uptake, the serine to glycine ratio was narrowed.”

“One possible explanation for the change in value of the activity ratio is that serine and threonine affect differently the binding of pyridoxal 5′-phosphate, thus altering differently the balance between the amount of active holoenzyme and inactive apoenzyme in the reaction systems.”

“Within the beta-site, indole and l-Ser react with pyridoxal 5'-phosphate in a two-stage reaction to give l-Trp.”

“The reaction of L-serine to form an external aldimine with pyridoxal phosphate at the active site of the K87T beta 2 subunit markedly increases the affinity for the alpha subunit and slows removal of pyridoxal phosphate by dialysis.”

“The fixation of the coenzyme pyridoxal 5'-phosphate and the substrate L-serine modifies the affinity constants of most of the antibodies for the enzyme, thus showing the existence of extended conformational rearrangements of the protein.”

“ l-Serine O-sulphate and l-threonine O-sulphate are degraded in the presence of pyridoxal 5'-phosphate to yield equimolar amounts of the corresponding keto acid, ammonia and sulphate.”

“Another of the B vitamins, pyridoxal , has been implicated in the biosynthesis of serine.”