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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Serine
drug:
Uridine Triacetate
Research Papers that Mention the Interaction
“From these observations we estimate that the phosphorylation of Thr 231, Ser 235, and Ser 262 contributes approximately 26, approximately 9, and approximately 33%, respectively, of the overall inhibition of tau binding to microtubules.”
Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules.“Phosphorylation of Ser and Thr residues has the potential to impact the local and global structure of Tau.”
“Phosphorylation of Tau at serine 422 promotes Tau aggregation.”
“CSF tau protein phosphorylated at serine 199 was increased (1.36 pM).”
“Using western blot, we found that QA treatment increased the phosphorylation of tau at serine 199/202, threonine 231 and serine 396/404 in a dose dependent manner.”
“ Tau is phosphorylated at serine (pSer) and threonine (pThr) in NFT, and NFT morphology varies according to phosphorylated sites and tau isoform.”
“Recently, we demonstrated that this unique group of serines and threonines has a critical role in controlling tau toxicity in a Drosophila model of tauopathy.”
Tau phosphorylation sites work in concert to promote neurotoxicity in vivo.“The phosphorylation of tau on serines and/or threonines occurs early in the disease course and altering phosphorylation has been shown to disrupt neuropathogenesis.”
Tau in MAPK Activation
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