Possible Interaction: Serine and Tyrosine

“Another isoform, p45 Dab1 [Dab1(271)], however, is phosphorylated by Cdk5 at one serine residue within a unique carboxyl-terminal region, and its serine phosphorylation enhances tyrosine phosphorylation by Fyn and results in progressive degradation of p45 Dab1.”

“The activation of these kinases appears to be order dependent, as it is enhanced when phosphorylation of tyrosine precedes that of serine but phosphorylation in the reverse order yields no activation.”

“Thus, Ser phosphorylation of MET determines cellular responsiveness to HGF depending on extracellular signals and modulates MET tyrosine phosphorylation and activation.”

“Phosphorylation on tyrosine and O-GlcNAcylation on nearby serine or threonine residues may modulate each other.”

“When AT1 receptors are activated by angiotensin II, serine phosphorylation of insulin receptor substrate-1 (IRS-1) inhibits tyrosine phosphorylation IRS-1 induced by insulin, leading to eventual reduction of glucose uptake.”

“The relative levels of serine phosphorylation and tyrosine phosphorylation are negatively correlated.”

“Importantly, serine 727 phosphorylation negatively modulates STAT3 tyrosine phosphorylation, which is required for dimer formation, nuclear translocation, and the DNA binding activity of this transcriptional regulator.”

“Non‐phosphorylated threonine, tyrosine and serine are conversely ineffective.”

“iv) Substitution of tyrosine 22 by serine lowered viral RNA packaging efficiency and yielded particles that were 400-fold less infectious; double mutant Tyr-22Thr-23----SerSer had the same infectivity as Tyr-22----Ser, whereas mutant Thr-23----Ser was fully infectious. (”

“Inhibition of both serine and tyrosine phosphorylation was observed.”