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“Vitamin B12 has been reported (Shive, 1950) to potentiate PABA action as, in its presence, higher concentrations of SA are required to inhibit the biosynthesis of methionine, xanthine and serine.”
“Later, Winkler and de Haan (1948) reported that, in the presence of methionine and adenine, serine and pteroylglutamic acid (or thymine) would reverse the inhibitory effects of higher concentrations of SAN.”