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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ Rapamycin fully inhibited mTORC1 and partially inhibited mTORC2 activities, including the phosphorylation of Akt ( serine 473) and PKCα, in vascular tumor cells.”
Vascular tumors have increased p70 S6-kinase activation and are inhibited by topical rapamycin“Inhibition of the kinase mTOR, a key player in the integration of nutrition and growth signals into protein synthesis, with rapamycin reduced serine phosphorylation of eIF3i and resulted in a loss of anchorage‐independent growth.”
“ Rapamycin inhibits S6K1-dependent IRS-1 serine phosphorylation, increases IRS-1 protein levels, and promotes association of tyrosine-phosphorylated IRS-1 with PI3K.”
“…,RAPA (especially at 1.2 mg/kg BW) decreased …-casein, and amino acid contents (Asp, Thr, Ser , Glu, Gly, Ala, Cys, Val, Met, Ile, Leu, Tyr, Lys, His, Arg, and Pro) of crop … of albumin, total protein, and uric acid in the serum of breeding pigeons (P < 0.05).”
Targeted disruption of TORC1 retards young squab growth by inhibiting the synthesis of crop milk protein in breeding pigeon (Columba livia)“…,RAPA (especially at 1.2 mg/kg BW) decreased …-casein, and amino acid contents (Asp, Thr, Ser , Glu, Gly, Ala, Cys, Val, Met, Ile, Leu, Tyr, Lys, His, Arg, and Pro) of crop … of albumin, total protein, and uric acid in the serum of breeding pigeons (P < 0.05).”
Targeted disruption of TORC1 retards young squab growth by inhibiting the synthesis of crop milk protein in breeding pigeon (Columba livia).“ Sirolimus , a specific inhibitor of mTOR pathway, inhibited MHV68-induced hepatic expression of serine p-IRS-1, increased total IRS-1 levels and improved MHV68-induced hepatic insulin resistance.”
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