Possible Interaction: Serine and Levetiracetam

“Application of LEV (10 μM) produced a significant decrease of amplitude of the Ca²⁺ current in SER neurons, although at this concentration of LEV there was no statistically significant decrease in the amplitude of Ca²⁺ current in Wistar rat neurons.”

“Furthermore, LEV (100 nM-1 mM) reduced the Ca²⁺ current in a concentration-dependent manner in both SER and Wistar rat neurons, but the inhibition was much more potent in the former neurons than in the latter.”

“ LEV (100 μM) also reduced Ca²⁺ current in SER type 2 neurons.”

“ LEV elevated the threshold potential level for activation of the Ca²⁺ … L-type Ca²⁺ current in type 1 neurons of SER , and the inhibitory action in type 2 neurons was much more potent than that …, suggesting that these effects contribute, at least partly, to the antiepileptic action of LEV.”

“Recently, we found that LEV inhibits the depolarization shift and accompanying repetitive firing induced by mossy fiber stimulation in CA3 neurons of SER hippocampal slices.”

“The application of LEV (100 μM) elevated the threshold for activation of the Ca²⁺ current, which was lowered in SER type 1 neurons and reduced the current size.”

“Therefore, this study was performed to determine whether LEV could inhibit the voltage-activated L-type Ca²⁺ current of hippocampal CA3 neurons obtained from SER and the non-epileptic Wistar rat.”