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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ Genistein inhibited inflammation-stimulated IRS-1 serine phosphorylation and restored insulin-mediated tyrosine phosphorylation.”
Positive and negative regulation of insulin action by genistein in the endothelium.“In addition, treatment with 30 µM genistein strongly induced phosphorylation of checkpoint kinase (CHK) 2 and p53 at serines 15, 20 and 37.”
“ Genistein , a broad-range protein tyrosine kinase inhibitor, inhibited the phosphorylation of these serines.”
“We previously showed that genistein , a naturally occurring isoflavonoid, induced increased ATM protein kinase activity, ATM-dependent phosphorylation of p53 on serine 15 and activation of the DNA-binding properties of p53.”
“Here we show that genistein induces the up-regulation of p53 protein, phosphorylation of p53 at serine 15 , activation of the sequence-specific DNA binding properties of p53, and phosphorylation of the hCds1/Chk2 protein kinase at threonine 68.”
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