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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“… l-serine powder to the patient’s food or drink over … more than a year increased the amount of d-serine in the plasma and cerebrospinal fluid and markedly improved all neurodevelopment assessments, suggesting that … treatment might be extended to various patients with disorders associated with NMDA receptor deficiency.”
l-Serine dietary supplementation is associated with clinical improvement of loss-of-function GRIN2B-related pediatric encephalopathy“The levels of d-serine in the brain are higher than many l-amino acids and account for as much as one-third of l-serine levels.”
“Thus, this study demonstrates that in mature neuronal circuits l-serine availability determines the rate of d-serine synthesis in the forebrain and controls NMDA receptor function at least in the hippocampus.”
“Likewise, l-serine O-sulfate inhibits the synthesis of d-serine in primary astrocyte cultures.”
“In CSF, we also confirmed a significant correlation between D-serine and L-serine levels in MDD (r = 0.72, p < 0.0001) and controls (r = 0.70, p < 0.0001).”
“The percentage of D-serine in the total serine of patients was significantly (z = -2.01, p = 0.044) lower than that of controls.”
“In addition, the percentage (%) of D-serine in the total (L+D) serine in the patients was significantly (z=-2.36, p=0.018) lower than that of controls.”
“In addition, … of D-serine in … total serine in the schizophrenic patients was significantly (z = -4.78, P<.001) lower than that of controls, suggesting that the activity of … racemase, an enzyme catalyzing the formation of D-serine from L-serine, may have been reduced in the schizophrenic patients.”
“ D-serine levels can be lowered by inhibiting the racemization of L-serine.”
Antinociceptive Effect of Rat D-Serine Racemase Inhibitors, L-Serine-O-Sulfate, and L-Erythro-3-Hydroxyaspartate in an Arthritic Pain Model“Administration of D-serine selectively increased its levels over L-serine , and vice versa.”
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