Possible Interaction: Selenium and Vitamin E

“Conclusion: In sera from patients with prostate cancer, selenium and vitamin E combined induced statistically significant proteomic pattern changes associated with prostate cancer–free status.”

“Conclusion: Consumption of designer eggs enriched in vitamin E, lutein, DHA and Se as part of normal diet for 8 weeks effectively increased the blood levels of α-tocopherol , lutein and DHA.Sponsorship: Scottish Office Agriculture, Environment, and Fisheries Department.”

“Results: Consumption of designer eggs enriched in vitamin E, lutein, Se and DHA significantly increased the levels of α-tocopherol , lutein and DHA in plasma as compared to the changes found after consumption of normal table eggs, with the largest increases found in plasma lutein (1.88-fold increase).”

“In association with cytotoxic chemotherapy selenium alone (P less than 0.05), vitamin E alone (P less than 0.… them together (P less than 0.001) decreased the plasma concentration of lipid peroxides, and the combination of selenium … vitamin E also increased the activity of … less than 0.01).”

“The inverse relationship between hepatic expression of 4 redox-related selenoprotein genes and vitamin E status revealed a novel interaction between Se and vitamin E in vivo.”

“The results suggested that vitamin E and selenium have synergistic effects on immune responses.”

“The results showed that the injection of selenium either alone or in combination with vitamin E significantly improved the production of specific antibodies against E coli, and that the production of specific antibodies was greater after the administration of selenium alone.”

“Cows receiving additional vitamin E had, on average, 6.1% fewer cases of retained placenta, whereby Se supplementation and breed were key factors improving the effect of vitamin E to reduce retained placenta.”

“ Vitamin E supplementation tended to decrease the calving to first estrus period (CFP), whereby supplementing Se and taking parity into account in the analysis significantly lowered the CFP.”

“Interestingly, pretreatment with selenium + vitamin E restored the levels of antioxidant enzymes, CAT and SOD, to the control values, whereas, oxidative stress indices, H2O2 and MDA, remained significantly high.”

“The recently finished follow-up of the Selenium and Vitamin E Cancer Prevention Trial (SELECT) even showed higher prostate cancer incidence in subjects who took α-tocopherol supplementation.”

“ Vitamin E and selenium (Se) interact synergistically as an important antioxidant defense mechanism.”