Possible Interaction: Selenium and Vitamin A

“Therefore, there are selenium antagonistic elements that inhibit the anticarcinogenic effects of selenium and other antioxidant micronutrients such as ascorbic acid, retinol , beta-carotene, alpha-tocopherol, and some other elements have a synergistic effect on the prevention of cancer.”

“The updated DVs may lead to … with respect to 8 vitamins vitamin A , thiamin, riboflavin, niacin, … 6 minerals (zinc, selenium , copper, chromium, molybdenum, and chloride), and have mixed effects on 2 vitamins where the amount …) (natural vitamin E compared with synthetic vitamin E and folic acid compared with folate).”

“Higher intake of vitamin A and selenium was also inversely associated with SCE level.”

“ Serum retinol and selenium were significantly lower among cases than among control group (p < 0.05 and p < 0.0001 respectively).”

“The results of experimental studies, carried out in research institutes in many parts of the world, suggest … coordinated supplementation of food with selenium may reduce the risk of cancer and moreover, the effect of selenium can be modified by … dietary factors, such as vitamin A and E. (…. 2, Ref.”

“Low vitamin A and E levels together with a marginally lowered selenium concentration may lead to a markedly decreased antioxidant capacity and enhanced eicosanoid production in RA.”

“Strong correlations were found between retinol and retinol-binding protein, prealbumin (transthyretin), alpha-tocopherol, and selenium.”

“In conclusion, the combined supplementary concentrations of vitamin A (16,000 IU/kg) and selenium (0.25 mg/kg) might be needed for better production and health of laying hens reared under heat stress conditions.”

“Higher dietary levels of vitamin E and Se increased the serum concentrations of retinol (1.66 vs. 2.20 microg/mL, p = 0.013) and a-tocopherol (3.33 vs. 1.71, p = 0.014), but they had no effect on the other physiological parameters.”

“… Se …), retinol (1.48 vs. 1.15 microg/mL, p = 0.001) and alpha-tocopherol (2.86 vs. 1.90 microg/mL, p = 0.001), the …, p = 0.040) as well as the total antioxidant status (TAS) of serum (0.38 vs. 0.28 mmol/L, p = 0.026).”

“Incidence of foot problems tended to be higher in the cows that received the combined selenium and vitamin A , D, E treatments.”