Possible Interaction: Selenium and Thyroxine

“We concluded that selenium status influences thyroid hormones in the elderly, mainly modulating T4 levels.”

“Correlation analysis of of the indexes: in HT patients, the basal serum selenium concentration was positively correlated with TT4 (r = 0.… (r = −0.343, p < 0.01), and had no significant correlation with TT3 (p > 0.05).ConclusionsThese findings indicated that levothyroxine … selenium combination results in … preventing CLT progression.”

“ Selenium might reduce antibody levels and result in a decreased dosage of LT4 and may provide other beneficial effects (e.g. on mood and health-related quality of life).”

“In the low selenium state thyroxine values are increased and decline during selenium supplementation, whereas tri-iodothyronine and thyroid stimulating hormone levels remain unchanged.”

“In iodine deficient hypothyroid children at low selenium dietary intake the supplementation of selenium induced a significant decrement of serum FT4 and T4 concentrations and an increase of serum TSH concentrations.”

“Furthermore, selenium had significant effects on the concentration of T4 and T3 (P < 0.05).”

“We found … selenium Se ) supplementation increased serum levels of triiodothyronine (…%, p b 0.001) and thyroxine (18%, p b 0.05) and promoted a tryptophan hydroxylase 2 (TPH 2) expression decrease (17%, p … 0.01) and tyrosine hydroxylase (TH) expression increase (202%, p b 0.01) in the hippocampus.”

“ Thyroxine was a potential biomarker of contaminant exposure in swallows of the Rio Grande, because it was negatively correlated with p,p'-DDE and Se.”

“Irrespective of the rate of development of renal failure, there were significant, non … functions) negative correlations between serum creatinine or urea concentrations and levels of T4 , FT4 and T3; rT3 levels remained unchanged, but …: T3 molar ratio fell from 236.5 ± 61 (± SE ) to 121.8 ± … (p < 0.05).”

“Plasma thyroxine (T4) was significantly increased when a semipurified diet was supplemented with either selenium or vitamin E. Triiodothyronine (T3) was also significantly increased by vitamin E and in one experiment with selenium supplementation.”