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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Selenium and Tamoxifen



Research Papers that Mention the Interaction

Tamoxifen treatment lowered levels of serum cholesterol by (mean +/- SE ) 12 +/- 2%, low density lipoprotein cholesterol by 19 +/- 3%, and fibrinogen by 18 +/- 4% (P < 0.0001 vs. placebo for each).
The Journal of clinical endocrinology and metabolism  •  1995  |  View Paper
Organic selenium may provide added benefit when combined with tamoxifen in adjuvant therapy or prevention.
Breast Cancer Research and Treatment  •  2008  |  View Paper
These results indicate that the growth inhibition synergy and reversal of tamoxifen resistance by combination of selenium with tamoxifen occurs via a tamoxifen-induced cell cycle arrest, allowing more cells to enter the intrinsic apoptotic pathway elicited by selenium. [
Molecular Cancer Therapeutics  •  2008  |  View Paper
However, tamoxifen reduced uptake [50% inhibitory dose, 8.6 +/- 0.9 ( SE ) microM] and competed for Ca2+ channel antagonist binding sites labeled by [3H]-(+)PN200-110 (ki = 2.2 +/- 0.3 microM).
Cancer research  •  1987  |  View Paper