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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Selenium and Sulindac

supplement:

Selenium

Research Papers that Mention the Interaction

Mechanistic studies revealed that the combination of selenium and sulindac led to the significant induction of the expression of p27 and p53 and JNK1 phosphorylation, and led to the suppression of β-catenin and its downstream targets.
ResultsWe fed the intestinal tumor model Apc/p21 mice with selenium- and sulindac-supplemented diet for 24 weeks, and found that the combination of selenium and sulindac significantly inhibited intestinal tumorigenesis, in terms of reducing tumor incidence by 52% and tumor multiplicities by 80% (p<0.01).
Journal of Hematology & Oncology  •  2013  |  View Paper