Possible Interaction: Selenium and Sulfur

“Synergistic relationship between Se and sulfur accumulation was observed in nearly all accessions at the selenate dosage applied.”

“Recently, the interaction between sulphur , in the same periodic group and therefore chemically similar, and selenium has been investigated in a bid to understand the role of both elements in disease.”

“ Se effects the toxicities of xenobiotic agents, provides antagonistic effect to Sulphur and co-administration with Zn increase Se retention in certain organs.”

“In general, we found that the selenium-containing derivatives were more potent than their isosteric sulfur analogs.”

“Overall, our results suggest that chemical interactions between Se and the sulfur of thiols are crucial for the toxicity mechanisms of Se.”

“Our studies demonstrate that substitution of sulfur with selenium in known iNOS inhibitor increases the compound's potency by several folds in variety of different cancers cell lines tested.”

“Postnatal nutritive muscular dystrophy, however, is attributed to either acute selenium and vitamin E deficiency in basic feed or impaired plant absorption of selenium as a result of antagonistic elements, such as sulphur.”

“Due to its chemical similarity to sulfur, Se in excess will nonspecifi cally replace sulfur in proteins, leading to the observed toxicity.”

“… sulfur … selenium causes a 10-fold increase in the Km of the enzyme for the favored substrate 3,3',5'-triiodothyronine (rT3), a 100-fold decrease … rT3 deiodination to competitive inhibition by gold and a 300-fold increase in the apparent Ki for uncompetitive inhibition by 6-n-propylthiouracil.”

“Organoselenium compounds, in general, are less stable and more reactive than the corresponding sulfur analogues and these properties may account for the toxicity of selenium when it is incorporated indiscriminately in place of sulfur in cellular constituents.”