Possible Interaction: Selenium and Selenomethionine

“None of the Se compounds were associated with any significant toxicities, and the total plasma Se AUC of SLM was markedly raised in comparison to MSC and SS.”

“Although SEMET supplementation increased blood selenium concentration more than MSC did, neither form had a more than minimal impact on the two major selenoproteins: selenoprotein P(SEPP1) and glutathione peroxidase(GPX).”

“ Selenomethionine significantly increased milk selenium concentrations whereas selenium-enriched yeast prevented a decline.”

“Increases in Se levels were significantly greater with selenomethionine than with the selenite supplement.”

“… Se into microbial … for SeMet (13.2-fold greater than no-Se control) compared with inorganic Se supplements (P = 0.02); no differences were observed between inorganic … (3.3-fold greater than no-Se control) and Na selenite (3.5-fold greater than no-Se control; P = 0.97).”

“Dietary supplementation with SeMet (2 mg/kg) increased the tissue concentration of Se , and the expression and activity of glutathione peroxidase, compared to non-supplemented controls.”

“Moreover, the ability of Se-Met to increase the Se levels in different tissues of the AD mice was more significant than that of Se-yeast.”

“The results showed that both Se-Met and Se-yeast not only significantly increased the Se levels, enhanced the antioxidant capacity and improved the cognitive decline in the model, but also decreased the Aβ and tau pathologies in the brain tissue of the AD mice.”

“Moreover, clinical studies have shown that after treatment with Myo-inositol plus seleniomethionine (Myo-Ins + Se ), TSH levels significantly declined in patients with subclinical hypothyroidism due to autoimmune thyroiditis.”

“Sodium selenite or selenomethionine at the same Se concentrations only slightly inhibited the hepatoma cells.”

“The selenomethionine raised plasma and albumin selenium concentrations.”