Possible Interaction: Selenium and Selenocysteine

“ Selenocysteine offers catalytic advantage to the protein repair function of Msrs, but also makes these proteins dependent on the supply of selenium and requires adjustments in their strategies for regeneration of active enzymes.”

“Biochemical and physicochemical properties of selenium result in the unique redox characteristics of selenocysteine and its use in antioxidant enzymes.”

“Not only did the level of the selenocysteine tRNA[Ser]Sec population increase approximately 20% in cells grown in the presence of selenium , but the distributions of the two isoacceptors also changed relative to each other.”

“ Selenium plays a central role in the formation of selenocysteine , a modified amino acid located in the catalytic center of selenoenzymes.”

“We reported previously that the presence of selenium in culture media of mammalian cells influences both the steady-state levels and distributions of two tRNA isoacceptors involved in the insertion of selenocysteine into protein in response to certain UGA codons.”

“ Elemental selenium is reduced to H2Se by selenocysteine or other reductants such as dithiothreitol, which is added to prepare selenocysteine from selenocysteine in the anaerobic reaction system.”

“Results of plant tissue Se accumulation analysis … a five-fold increase in tissue selenocysteine concentration … Se increased from 5.07 to 22.02 mg kg-1, but there was no further increase in … when the tissue total Se concentration increased from 22.0 to 117.4 mg kg-1.”