Possible Interaction: Selenium and Beta Carotene

“The mean (+/- standard deviation) concentrations of plasma …-carotene, alpha-tocopherol, vitamin C, selenium and zinc among participants who were randomly … to receive a daily supplementation with beta-carotene , vitamin E, vitamin C, selenium and zinc for 2 years were significantly higher than those who were assigned to receive placebo.”

“Similarly, a significant increase in GSH values was observed at 12 mo compared with baseline both after selenium supplementation (P < 0.001) and beta-carotene supplementation (P < 0.01).”

“Therefore, there are selenium antagonistic elements that inhibit the anticarcinogenic effects of selenium and other antioxidant micronutrients such as ascorbic acid, retinol, beta-carotene , alpha-tocopherol, and some other elements have a synergistic effect on the prevention of cancer.”

“It's shown that there is a combined deficiency of beta-carotene and selenium and occasionally some other micronutrients in a significant part of the patients.”

“ beta-Carotene + retinol (2.14 + 0.009), in combination, and selenium (0.0022) were ineffective.”

“Carotenoids beta-carotene and xanthophylls) and chlorophyll (Chl a and Chl b) contents in cells exposed to Se 50 mg/L increased primarily and decreased afterwards, while photosynthetic pigments in cells exposed to Se 800 mg/L decreased significantly.”

“Results: Selenium and selenium plus beta-carotene supplementation caused an increase in total T cells by 27% and 31%, respectively (p <.05).”

“ Selenium plus beta-carotene supplementation caused an increase in the percentage of NK cell by 121% and 161% at 3 and 6 months, respectively.”