Possible Interaction: Selenium and Aldesleukin

“The results from studies on mice inoculated with SQCC cells expressing the … (IL-2) and supplemented with Se (2.00 ppm) indicated that Se significantly retards the clinical appearance of … of 2,000 IU of IL-2 resulted in 50% reduction in the … tumors and 72% of early tumors.”

“ Selenium might enhance IL-2 production and response through the augmentation of IL-1 production and response, thereby promoting the enhancement of the proliferation and action of T lymphocytes and other immunocompetent cells.”

“The inhibition by IL-2 was dose dependent, and the maximal inhibition of PRL release after 5 days of exposure to IL-2 was 71.0 +/- 0.9% (mean +/- SE).”

“It was concluded that 0.… and 0.8 mg/kg Se could increase the decreased percentages of peripheral … T-cell subsets and the contents of serum IL-2 and IFN-γ induced by 0.3mg/kg AFB1 in the diets, and cellular immune function could be improved in chickens.”

“ Se appears to enhance the lytic activity of activated NK cells and to augment the proliferation, expansion, and lytic activity of A-LAK cells in the presence of high concentrations of Il-2 through its ability to enhance the expression of intermediate affinity Il-2R on these cells.”

“RESULTS: Treatment of established tumors in hosts supplemented with Se with peritumoral injections of IL-2 resulted in 50% reduction of tumor size, whereas treatment of early tumors resulted in 72.4% reduction.”

“ Selenium at 10 ng/ml enhanced IL-2 production nearly twofold and lithium at 42 ng/ml also enhanced IL-2 production by nearly twofold.”