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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Selenate, Sodium
drug:
Uridine Triacetate
Research Papers that Mention the Interaction
“In vitro, sodium selenate reduced tau phosphorylation in human neuroblastoma cells and reversed the increase in tau phosphorylation induced by the PP2A inhibitor, okadaic acid.”
Targeting hyperphosphorylated tau with sodium selenate suppresses seizures in rodent models“Acute treatment of either neuroblastoma cells or normal aged mice with sodium selenate rapidly reduced tau protein phosphorylation.”
“Previous work by our group has shown sodium selenate upregulates the activity of protein phosphatase 2 in the brain, increasing the rate of tau dephosphorylation.”
“ Sodium selenate has been recently found to reduce tau hyperphosphorylation and NFTs formation, and to improve spatial learning and motor performance in AD mice.”
“ Sodium selenate up-regulates PP2A/PR55 and dephosphorylates tau , and may hold promise as a treatment in the mild brain injury setting.”
Sodium selenate, a protein phosphatase 2A activator, mitigates hyperphosphorylated tau and improves repeated mild traumatic brain injury outcomes“Here, we identify sodium selenate as a compound that reduces tau phosphorylation both in vitro and in vivo.”
“Taken together, sodium selenate mitigates tau pathology in several AD models, making it a promising lead compound for tau-targeted treatments of AD and related dementias.”
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