Possible Interaction: Secretin and Trypsin

“The integrated immunoreactive trypsin response to secretin injection in patients with mild to moderate insufficiency was significantly higher compared to controls and to patients with severe insufficiency.”

“After secretin stimulation there was a significant abnormal increase in serum trypsin (p less than 0.01) in 34 patients with proven chronic pancreatitis associated with mild to moderate dysfunction (groups I-II), no rise if there was marked insufficiency (group III).”

“ Trypsin and amylase reaction patterns differed during secretin stimulation, with a rise in the amylase occurring at the expense of pancreas isoamylase.”

“ Secretin injection evokes a significantly different response in the serum kinetics of trypsin and amylase, due probably to their difference in molecular weight (21,000 vs 52,000 Daltons).”

“ Secretin administration led to decreases in specific activities of trypsin and chymotrypsin compared to post-CCK levels.”

“It was possible to show that pancreatic output of trypsin increased with increasing dose rates of secretin at low levels of stimulation, while high doses of secretin inhibited trypsin secretion by the pancreas.”