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Discover Supplement-Drug Interactions

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Possible Interaction: Secretin and Substance P



Research Papers that Mention the Interaction

Secretin (10 nM) stimulated HCO(3)(-) secretion by sealed, nonperfused, ducts about threefold, and this effect was totally inhibited by SP (20 nM).
American journal of physiology. Cell physiology  •  2005  |  View Paper
We found that secretin can stimulate HCO3- secretion in guinea pig pancreatic ducts about fivefold and that this effect could be totally blocked by SP.
American journal of physiology. Cell physiology  •  2003  |  View Paper
In anesthetized dogs infused with a background dose of secretin (82 pmol/kg per h), addition of SP , SK and NK caused an immediate and dose-dependent increase in the pancreatic blood flow, oxygen consumption and pancreatic secretion accompanied by a dose-dependent decrease in arterial blood pressure.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society  •  1992  |  View Paper
When SP was superimposed on cholecystokinin (CCK)- or secretin-induced choleresis, all CCK-induced effects were abolished, whereas SP had a less pronounced anticholeretic effect when choleresis was induced by secretin.
Scandinavian journal of gastroenterology  •  1984  |  View Paper