Possible Interaction: Secretin and Somatostatin

“ Secretin inhibited acid secretion by 54% (p less than 0.05), and somatostatin inhibited by 70% (p less than 0.05).”

“The combined infusion of secretin and somatostatin decreased acid output by 64% (p less than 0.05).”

“The inhibitory effect of intravenous infusion of secretin (0.05 CU kg-1h-1) and somatostatin (60 pmol kg-1h-1), given alone or in combination, on pentagastrin-stimulated (100 ng kg-1 h-1) acid secretion was studied in 10 healthy subjects.”

“The pattern of inhibition of amylase and chymotrypsin secretion is different and difficult to interpret from the present study, but somatostatin may inhibit also the secretin stimulated pancreatic secretion of enzymes completely, as the inhibitory effect seemed to decline when larger doses of secretin were applied.”

“The pattern of inhibition suggests that somatostatin is a competitive inhibitor of secretin in the stimulation of pancreatic secretion of bicarbonate, which supports the hypothesis of a direct effect of somatostatin on the exocrine secretory cells of the pancreas.”

“The secretion of bicarbonate, amylase, and chymotrypsin in response to secretin was significantly reduced by somatostatin.”

“ Somatostatin is a hypothalamic peptide hormone that inhibits the secretion of growth hormone, glucagon, insulin, gastrin and secretin , and also plays a role in neural transmission.”

“Somatostatin probably inhibits pancreatic exocrine secretion by a variety of mechanisms which depend on … the type of secretion studied (postprandial vs. interdigestive secretion, protein vs. bicarbonate secretion): Somatostatin may act via inhibition of the … hormones such as cholecystokinin (CCK) and secretin or via intrapancreatic inhibition … or action of CCK.”

“In addition to its well-known growth hormone inhibition properties, somatostatin inhibits the release or action of thyrotropin, insulin, glucagon, secretin , gastrin, cholecystokinin, gastric inhibitory polypeptide (GIP), pancreatic polypeptide, neurotensin, and motilin.”

“To minimize any possible error in the estimation of insulin removal as a result of endogenous insulin, pancreatic insulin secretion was suppressed by intravenous administration of somatostatin (500 micrograms/h).”

“Since secretin and somatostatin differ in their respective effects on gastrointestinal blood flow it is suggested that the previously reported beneficial effects of both peptides on upper gastrointestinal bleeding cannot solely be attributed to changes in regional blood flow.”

“ Secretin at a concentration of 0.3 U/ml and gastric inhibitory polypeptide concentration of 58 ng/ml produced a prompt twoto threefold rise in mean somatostatin release, which persisted throughout the perfusion period.”

“A few cases have been reported in the literature, complete shrinkage of a pituitary GH secreting macroadenoma after long-term somatostatin analogue administration.”

“Therapy with somatostatin analogues (SSAs) induce control of GH and IGF-I excess in the majority of patients, but their inhibitory effect on pancreatic insulin secretion might complicate the overall effect of this treatment on glucose tolerance.”