Possible Interaction: Secretin and Sincalide

“Maximal trypsin output during infusions of CCK-8 was significantly less than that after a combination of the CCK-like peptide, caerulein, and secretin (32.95 +/- 2.16 k-i.u./30 min, P less than 0.001).”

“ CCK-OP plus secretin produced only small increases in plasma HPP levels, whereas values after all doses of CCK were significantly higher (p < 0.05) and were similar to values caused by a meal.”

“ CCK-OP , in a dose of 40 ng/kg/hr given simultaneously with intravenously administered secretin , produced maximal pancreatic enzyme secretion and gallbladder contraction, comparable to that induced by CCK.”

“In the rat, an … 46 ng of CCK-8 produced a 300% increase in immunoreactive … CCK levels (2 min) and caused peak pancreatic protein secretion within 5 min; 4 fold lower doses (11.5 ng) elevated plasma … by 38% and pancreatic protein secretion to a small but significant extent.”

“Thus, cholecystokinin-octapeptide in a relatively small dose range potentiated the pancreatic bicarbonate secretion stimulated by a physiologic dose of secretin.”

“When pancreatic exocrine secretion was stimulated by secretin plus CCK-8 , KSG-504 suppressed the increases in juice volume and bicarbonate output to the level stimulated by secretin alone.”

“In in vitro study, a combined administration of secretin and carbachol or cholecystokinin octapeptide (CCK-8) to the culture medium of chief cells potentiated pepsinogen secretion.”

“Simultaneous application of CCK-8 and secretin (all 100 pM) failed to elicit either a potentiation or an additive effect in both pancreatic juice flow and total protein output.”

“The effect of CCK-8 was three-fold larger compared to the responses obtained with secretin alone.”

“The net increases in both secretory parameters were reduced during combined application of CCK-8 and secretin compared to the responses obtained with CCK-8 alone.”

“Simultaneous intra-arterial infusion of secretin and CCK-8 in doses of 0.75 and 4.2 pmol/h; respectively, significantly increased volume, bicarbonate, and protein output in 7 rat pancreata (P < 0.01).”

“In addition, compared to basal autograft secretion, OP-CCK and OP-CCK plus secretin stimulation resulted in a sustained and significant increase in urinary amylase and protein secretion, indicating preserved sensitivity of the denervated pancreas to exogenous hormones.”

“Recording total protein output, monitored on-line at 280 nm, from superfused rat pancreatic segments, we demonstrate that secretin (a cAMP-acting hormone) reduces the efficacy of the calcium-mediated secretagogue cholecystokinin-octapeptide ( CCK-8).”