Possible Interaction: Secretin and Polypeptides

“The fluorescence reaction was not blocked by an excess amount of gastrin, cholecystokinin, glucagon, vasoactive intestinal polypeptide , or motilin, whereas secretin blocked the reaction.”

“CONCLUSIONS Se retin at pharmacological doses is a powerful stimulus for PP re lease.”

“OBJECTIVE Intravenously administered secretin stimulates pancreatic polypeptide ( PP ) release in patients with endocrine enteropancreatic tumors, but data in patients with nontumorous disorders are controversial.”

“After intravenous administration of secretin , individually divergent increases in plasma PP concentration can be observed hampering interpretation of the stimulation test.”

“In diabetic patients plasma levels of pancreatic polypeptide PP ) increased four fold after intramuscular injection of secretin (50 CHRU, Eisai Co.) in spite of the lack of response of plasma insulin, plasma glucagon and blood glucose levels.”

“ PP and PYY significantly inhibited secretin/ CCK-8-induced pancreatic exocrine secretion.”

“Therefore, the supraphysiological dose of secretin stimulates PP secretion probably via an intrapancreatic release of acetylcholine, while caerulein stimulates IRI secretion by a direct action.”

“ PP decreased optimal amylase release evoked by OP-CCK and OP-CCK plus secretin.”

“We conclude that exogenous doses of PP that produce smaller increments in PP concentration than those seen after feeding inhibit pancreatic bicarbonate and protein secretion stimulated by secretin and caerulein.”

“In contrast, vasoactive intestinal polypeptide , which stimulates pancreatic fluid and bicarbonate secretion, showed a competitive inhibition of secretin binding to the plasma membrane preparation.”