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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Secretin
drug:
Nitroarginine
Research Papers that Mention the Interaction
“A possible explanation for this observation is that smaller volumes of nutrient … delivered into the duodenum; however, it could also be that postprandial pancreaticobiliary secretion is inhibited by an alteration of blood flow or by a … in contractions of the sphincter of Oddi after the administration of L-NNA.”
Effects of nitric oxide synthase inhibitor on the digestive system measured by simultaneous monitoring of gastric motility, gastric emptying activity and postprandial pancreaticobiliary secretion in dogs.“administration of L-NNA (2.5 mg/kg + 0.5 mg/kg-h), an inhibitor of NO synthase, the pancreatic secretory responses to SF, F, duodenal nutrient, GRP and urecholine were significantly inhibited by about 74%, 70%, 70%, 80% and 30%, respectively.”
“In anesthetized dogs, infusion of NG-nitro-L-arginine caused a significant reduction in the pancreatic blood flow both while resting and following stimulation with secretin plus cholecystokinin but did not affect this flow in animals treated with glyceryl trinitrate.”
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