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“Synthetic human secretin augments the ion product of calcium and carbonate in human hepatic bile, increasing the tendency for calcium carbonate precipitation.”
“The administration of rapid calcium followed by secretin provoked the greatest increases in serum gastrin above basal levels in both normals (29%) and patients (362%).”
The American journal of digestive diseases • 1967 | View Paper
“Basal, forskolin- and secretin plus guanosine 5’-[γ-thio]trisphosphate-stimulated adenylate cyclase activity were inhibited by protein kinase C in the presence of Ca++.”
“As both the D50 for secretin-induced response increased, and the maximal secretory response decreased, if may be concluded that calcium treatment decreased the sensitivity of duct cells to secretin and reduced their secretory capacity. (”